While working on an art piece I was closing out of the program with the usual "File has been modified would you like to save?" in the prosses of trying to save the file (I some how) unplugged my flash drive from my laptop and the file was unable to save/locate the original file. Now the file will not open, Krita will open with a different window with the message file could not be open and the reason being an invalid Krita file.

I went ahead and looking through different threads for invalid files on krita and tried compressing the file into a zip folder to fix it that way, it didn't work. I've already tried restarting my laptop and uninstalled and reinstalled Krita to no avail. Is there anyway possible to recover the file?

If you broke the file by removing the disk while saving was going on, it might be completely lost.

* uninstalling and reinstalling Krita is useless in this case: that cannot fix the broken file on your external drive
* same for restarting the laptop
* you misunderstood the zip file thing: the thing to do is to rename your .kra file to .zip (you might have to enable view extensions in explorer, I'm assuming you're using windows, because you don't say so). Try to repair the renamed file with ziprepair pro.

Also, check whether there's a backup file -- that has a .kra~ extension, not a .kra. Rename to file_bak.kra and try to open it.