I work in a Exchange 2010 environment and when I get meeting invite emails and "accept" them they populate into my calendar just fine, but they also send out an email to the sender. Can this be disabled, so I can still "accept" the meeting, have it populate my calendar, but not send an email?

Disable the checkbox "Use groupware communication" in the groupd scheme planning tab of the korganizer configuration dialog to stop emails being generated. There appear to be no finegrained configuration.