I've been having this problem in where krita doesn't correctly react to the cursor on my screen, creating a cursor offset and changing my tablet's pressure sensitivity, when minimizing the cursor offset is even more obvious because the cursor can fully go outside the program but when coming inside it, the cursor is already on the middle of the screen.
At first i thought this was a Wintab problem so i changed the tablet API to Windows Ink with no real results, which is odd because i run the same tablet on the same hardware on Ubuntu 18.04 but it works perfectly in that operating system.
I have 2 monitors, the main one is a 5:4 one and the second one is 16:9, if that helps on the cursor offset problem.

I have no custom pressure settings, i haven't changed any tablet settings aside from the API, and i have re-downloaded and re-installed the program several times, with no changes.
a small recording of what i described can be found bellow:
https://www.youtube.com/watch?v=4QFiag-3Ycg

PC specs if it's any rendering problem:
OS: Windows 10 64bit, 8gb RAM, Nvidia 740 2GB DDR3 OpenGL 4.4, AMD FX 6350

Curiously enough, you don't mention what brand and type tablet you're using. We know that Wacom messed up with their latest driver revision: they fixed a bug, but the fix broke Krita.

In any case, redownloading and reinstalling Krita -- that NEVER makes ANY difference. You could try to reset Krita's settings: see the FAQ for that, you could swapping which display is the main one, but reinstalling Krita is an exercise in futility.

Yup, I updated my Wacom driver for an Intuos 4 tablet and installed Krita 4.1 on the same day. What I was thinking I don't know making two changes at once but I had the offest issue immediately. After backing my Wacom driver back to the previous version everything worked perfectly. In my case, Krita had nothing to do with the issue.

Yes, we're working with Wacom right now to come to a solution.

Found a workaround.
I have an identical setup to OP except for the hardware, and my workaround was to do the shift menu and set the screen size manually to the screen size of the monitor you're drawing on, plus whatever was missing from the bottom of the canvas. for me it was missing some 1.6 inches of tablet area or something. So what I did was calculated the number of pixels I was missing proportionally from the amount of inches of tablet area, and add it to the height, so i wound up with 1920x1250 as my manual size and it seems to work almost perfectly.

edit: with this workaround non-brush tools are offset.

So, I've used krita for months now and it's worked perfectly. Due to an unrelated situation, however, I had to restore my computer to factory settings and re-setup everything i had. Since then, krita has operated a little differently. The cursor is off set whenever I go from the windows on any sides to the canvas and whenever i open krita with my tablet on a window opens stating, "Choose screen resolution: The driver for your drawing tablet and Windows do not agree on the size of the screen that your tablet is connected to. please select the right option." I've tried playing with other options but everything I've tried makes it worse and I'm confident the resolution should be at 1920x1080.

I use a Dell two-in-one laptop with a Huion graphics tablet: 680s.

Any help would be greatly appreciated, I'm itching to get some art done!

Hi on3punchd4ndy,

There was a discussion on this topic here:

https://answers.microsoft.com/en-us/win ... 685d8760c6

one of the answers found was:

The issue that you’ve encountered regarding the behavior of the program that you are using your device may be caused by some configuration or the driver on your PC is not yet updated. To sort out your concern, we’d like to know the following information:

Were there any changes that happened prior to the issue?
What are the troubleshooting steps you've done so far?
Which version of Windows are you using?
Have you installed the latest update on your PC?
To check for the latest update, go to Windows Update by clicking Start > Settings > Update & security and click Check for updates. It will scan and install all the latest updates available for your device.