I have configured my mouse to be left-handed in System Settings > Input Devices > Mouse. However, when I reboot, the mouse becomes right-handed, although it still shows as left-handed in System Settings. I have to change it to right-handed, apply, and then change it back to left-handed and apply in order for it to work. Then it will lose the setting again on reboot. Pain. Any ideas?

Same problem here! Just happened after recent update. Discrimination against lefties!

I also have a problem, except in my case, the left handed mouse setting never takes effect. Even tried clean home directory and setting this again, but still have the same problem.

similar problem on Tumbleweed - except resetting the mouse disables all menu activity